The ability of a bacterium to establish an infection within a host is dependent on both host and pathogen factors. Classically, the model organism for study host-pathogen interactions with Salmonella has been the mouse. Recently, the nematode Caenorhabditis elegans has been used as an alternative to the mouse model for a variety of bacteria. Previous literature has shown thatS almonella enterica server Typhimurium is able to establish infection in C. elegans. Current projects aim to characterize the C. elegans model for other serovars, as well as identify virulence factors of Salmonella important for virulence and host factors that prevent infection.