Salmonella enterica is the leading cause of bacterial foodborne disease in the U.S., with an estimated 1 million cases, 19,336 hospitalizations, and approximately 378 deaths each year. Not only isSalmonella a public health concern due to the number of infections but also due to resistance to antimicrobial agents. Many strains harbor numerous resistance genes that encoded resistance to a variety of antimicrobial compounds and these genes are often encoded on transmissible plasmids. Research in my lab has focused on characterizing the resistance genes found in various Salmonella serovars. Results from these studies found that resistance genes were widely disseminated among strains of numerous serovars and were not clonal.