Not only do Salmonella isolates carry numerous resistance genes, these resistance genes are often carried on transmissible plasmids. Currently, plasmid sequencing studies are being conduct with collaborators from the U.S. Food and Drug Administration. A 135 kb Inc A/C plasmid containing resistance genes associated with resistance to at nine different antimicrobials has be sequenced from a Salmonella enterica serovar Heidelberg isolate. A number of other large resistance plasmid from other serovars are being sequenced and analyzed.
Antimicrobial Resistance Plasmids